Author

Lorenzo Vaccaro

Telethon Institute Of Genetics And MedicineORCID 0000-0002-8233-3241Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Bioinformatics· 1 Cell Biology· 1 Neuroscience· 1

Signature Assays, Organisms & Methods

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Organism:human· 3 Assay:bulk RNA-seq· 2 Approach:experimental assay· 2 Approach:statistical model· 2 Research Focus:cell type annotation· 1 Research Focus:differential expression· 1 Research Focus:drug response / drug discovery· 1 Research Focus:gene regulatory network inference· 1

Frequent Co-Authors

Davide CacchiarelliiD· 3 shared Akira HasegawaiD· 1 shared Alexey L. KhodjakoviD· 1 shared Antonella IulianoiD· 1 shared Ashish JainiD· 1 shared Bruno GoudiD· 1 shared Delaney Wood· 1 shared Diego di BernardoiD· 1 shared

Activity by Year

2021-2025 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 19 mutual co-author links

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3 shared papersCell Biology

Davide CacchiarelliORCID

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Author profile →

3 papers

Recent·Most cited

De novo Golgi biogenesis requires coordinated transactivation of a Golgi regulon

Francesca Forno, Domenico Abete, Elena Polishchuk, Xabier Bujanda Cundin, Fioranna Renda, Roberta Crispino, Josephine Salzano, Raffaella Petruzzelli, Rossella De Cegli, Martina Sofia, Nicolina Cristina Sorrentino, Lorenzo Vaccaro, Davide Cacchiarelli, Juul Verbakel, Jan de Boer, , Roman Polishchuk

The paper identifies a Golgi regulon and shows CREB3L1 drives its transcriptional activation during de novo Golgi biogenesis.

bioRxiv · Sep 17, 2025 · PreprintCell Biology

Excitatory Cortical Neurons from CDKL5 Deficiency Disorder Patient-Derived Organoids Show Early Hyperexcitability Not Identified in Neurogenin2 Induced Neurons

Madison R. Glass, Dosh Whye, Nickesha Camille Anderson, Delaney Wood, Nina R. Makhortova, Taryn J. Polanco, Kristina H. Kim, Kathleen E. Donovan, Gayathri Rajaram Srinivasan, Lorenzo Vaccaro, Ashish Jain, Davide Cacchiarelli, Liang Sun, Heather E. Olson, Elizabeth D. Buttermore, Mustafa Şahin

This study compares neuronal activity and gene expression in CDD patient-derived neurons from two differentiation methods, finding early hyperexcitability in organoid-derived neurons but not induced neurons.

Neurobiology of Disease · Sep 8, 2025Peer-reviewedNeuroscience

Automatic identification of small molecules that promote cell conversion and reprogramming

Francesco Napolitano, Trisevgeni Rapakoulia, Patrizia Annunziata, Akira Hasegawa, Mélissa Cardon, Sara Napolitano, Lorenzo Vaccaro, Antonella Iuliano, Luca G. Wanderlingh, Takeya Kasukawa, Diego L. Medina, Davide Cacchiarelli, Xin Gao, Diego di Bernardo, Erik Arner

DECCODE identifies small molecules that enhance cell reprogramming and conversion using transcriptional data and drug profiles.

Stem Cell Reports · Apr 22, 2021Peer-reviewedBioinformatics