Rossella De Cegli

ALTERATIONS IN PEROXISOMAL-MITOCHONDRIAL INTERPLAY IN SKELETAL MUSCLE ACCELERATES MUSCLE DYSFUNCTION

This study shows that disrupting peroxisomal-mitochondrial interactions in skeletal muscle accelerates muscle dysfunction and age-related degeneration.

De novo Golgi biogenesis requires coordinated transactivation of a Golgi regulon

The paper identifies a Golgi regulon and shows CREB3L1 drives its transcriptional activation during de novo Golgi biogenesis.

Ezrin defines TSC complex activation at endosomal compartments through EGFR-AKT signaling.

The paper identifies Ezrin's role in regulating TSC complex activation at endosomes via EGFR-AKT signaling, showing its impact on mTORC1 and retinal function.

CHOP-c-JUN complex plays a critical role in liver proteotoxicity induced by mutant Z alpha-1 antitrypsin.

The paper identifies the CHOP-c-JUN complex as a key driver of liver proteotoxicity in AAT deficiency by enhancing SERPINA1 transcription and ATZ accumulation.