Helen M. Lazear

The La Crosse virus M segment determines virus isolate cell-to-cell spread and virulence

This study identifies the M segment of La Crosse virus as a key determinant of cell-to-cell spread, virulence, and plaque size across different viral isolates.

No-known-vector flaviviruses exhibit diverse replication and virulence phenotypes in mice

This study evaluates the virulence and replication of 12 no-known-vector flaviviruses (NKVFVs) in mice, showing that seven are lethal in immunocompromised mice and all replicate in mouse cells.

Interferon lambda signaling to maternal dendritic cells protects against congenital Zika virus infection

This study shows that maternal IFN-lambda signaling to dendritic cells reduces transplacental ZIKV transmission in mice.

Altered m6A modification of specific cellular transcripts affects Flaviviridae infection

This study shows that Flaviviridae viruses alter m6A modification of specific host transcripts, affecting viral infection through changes in translation and splicing.