Sachie Kanatani

A Plasmodium falciparum PX1 haplotype is associated with reduced susceptibility to artemisinin and lumefantrine

This study identifies a PX1 haplotype in Plasmodium falciparum associated with reduced susceptibility to artemisinin and lumefantrine, providing a marker for drug resistance surveillance.

Identification of UCB-9721 as a potent inhibitor of MyoA, the essential class XIV myosin motor of apicomplexan parasites

This paper identifies UCB-9721 as a potent inhibitor of T. gondii MyoA, showing greater potency than KNX-002 and inhibiting related apicomplexan parasites.

Dynamic regulation of long non-coding RNAs across asexual andgametocyte development in Plasmodium falciparum

This study identifies and characterizes long non-coding RNAs in Plasmodium falciparum across asexual and gametocyte stages using long-read sequencing and single-cell transcriptomics.

B Lymphocyte Protein Factories produced by Hematopoietic Stem Cell Gene Editing

This study uses gene-edited hematopoietic stem cells to create long-lived B lymphocyte protein factories that produce therapeutic antibodies against HIV-1, malaria, and influenza.

High-Resolution Proteomics Unveils Salivary Gland Disruption and Saliva-Hemolymph Protein Exchange in Plasmodium-Infected Mosquitoes

This study uses high-resolution proteomics to show that Plasmodium infection disrupts mosquito salivary glands, causing exchange of proteins between hemolymph and saliva.

Degradation of ribosomal RNA during Plasmodium falciparum gametocytogenesis

This study investigates rRNA dynamics in Plasmodium falciparum during gametocytogenesis, revealing specific degradation patterns and shifts in rRNA types across developmental stages.

The major surface protein of malaria sporozoites is GPI-anchored to the plasma membrane

This study confirms that the circumsporozoite protein (CSP) of Plasmodium sporozoites is GPI-anchored using metabolic labeling and mass spectrometry.

Spatial Transcriptomics to define transcriptional patterns of zonation and structural components in the liver

This study uses spatial transcriptomics to analyze liver tissue, revealing zonation patterns and previously uncharacterized structures in the spatial transcriptome.