Author

Chad Liu

Chan Zuckerberg Biohub San FranciscoORCID 0000-0002-8345-8847Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Bioinformatics· 1 Systems Biology· 1

Signature Assays, Organisms & Methods

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Research Focus:benchmarking· 2 Approach:deep learning· 2 Organism:human· 2 Assay:imaging· 2 Organism:mouse· 1 Assay:scRNA-seq· 1 Assay:spatial transcriptomics· 1 Organism:zebrafish· 1

Frequent Co-Authors

Carolina AriasiD· 2 shared Eduardo Hirata-MiyasakiiD· 2 shared Ivan E. IvanoviD· 2 shared Manuel D. LeonettiiD· 2 shared Shalin B. MehtaiD· 2 shared Talon ChandleriD· 2 shared Ziwen LiuiD· 2 shared Adrián JacoboiD· 1 shared

Activity by Year

2024-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 43 mutual co-author links

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2 shared papersSystems Biology

Carolina AriasORCID

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2 papers

Recent·Most cited

A multimodal perturbation atlas defines the phenotypic resolution of cellular morphology.

Chad Liu, Alexander V. Hillsley, Madhurya Sekhar, Cassidy Jones, Gabriel Sturm, Taihei Fujimori, Diane M. Wiener, Karen W. Cheng, Talon Chandler, Alexander Lin, Duo Peng, Max Frank, Leah C. Dorman, Ilakkiyan Jeyakumar, Ivan E. Ivanov, , Manuel D. Leonetti

The paper presents a multimodal perturbation atlas using CRISPR knockouts in A549 cells, combining microscopy, phase imaging, and scRNA-seq to assess phenotypic resolution.

bioRxiv · Aug 25, 2026 · PreprintSystems Biology

Robust virtual staining of landmark organelles

Ziwen Liu, Eduardo Hirata-Miyasaki, Soorya Pradeep, Johanna V. Rahm, Christian Foley, Talon Chandler, Ivan E. Ivanov, Hunter O. Woosley, Tiger Lao, Akilandeswari Balasubramanian, Rita Marreiros, Chad Liu, Manuel D. Leonetti, Ranen Aviner, Carolina Arias, , Shalin B. Mehta

The paper develops robust virtual staining methods for cellular landmarks using deep learning, showing improved performance across cell types and imaging conditions.

bioRxiv · May 31, 2024 · PreprintBioinformatics