Author

Lars M. König

LMU KlinikumORCID 0000-0002-8348-7787Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Biochemistry· 1 Bioinformatics· 1 Molecular Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Organism:human· 2 Research Focus:batch correction / integration· 1 Approach:deep learning· 1 Research Focus:dimensionality reduction· 1 Research Focus:host-pathogen & immune response· 1 Research Focus:imputation· 1 Assay:structural biology· 1

Frequent Co-Authors

Adil MericiD· 1 shared Adrian F. SchnelliD· 1 shared Alexander Henrici· 1 shared Andreas PichlmairiD· 1 shared Camille Stephan‐Otto AttoliniiD· 1 shared Carina C. de Oliveira ManniD· 1 shared Dorota KmiećiD· 1 shared Fabian Joachim TheisiD· 1 shared

Activity by Year

2020-2025 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 22 mutual co-author links

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1 shared paperBioinformatics

Adil MericORCID

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

Structural Basis for OAS2 Regulation and its Antiviral Function

Veronika Merold, Indra Bekere, Stefanie Kretschmer, Adrian F. Schnell, Dorota Kmieć, Rinu Sivarajan, Katja Lammens, Rou Liu, Julia Mergner, Julia Teppert, Maximilian Hirschenberger, Alexander Henrici, Sarah Hammes, Kathrin Buder, Marcus Weitz, , Carina C. de Oliveira Mann

This study reveals the structural basis of OAS2 regulation and its antiviral function, showing how it discriminates RNA length and restricts viruses like coronaviruses.

Molecular Cell · May 23, 2025Peer-reviewedBiochemistry

flowVI: Flow Cytometry Variational Inference

Kemal İnecik, Adil Meric, Lars M. König, Fabian Joachim Theis

flowVI is a deep generative model for integrating flow cytometry datasets, improving imputation and enabling atlas construction by modeling noise and batch effects.

bioRxiv · Nov 10, 2023 · PreprintBioinformatics

Tousled-like kinase activity is required for transcriptional silencing and suppression of innate immune signaling

Sandra Segura‐Bayona, Marina Villamor-Payà, Camille Stephan‐Otto Attolini, Lars M. König, María Sanchiz-Calvo, Simon J. Boulton, Travis H. Stracker

This study shows TLK1/2 activity protects replication forks, contributes to chromatin silencing, and suppresses innate immune responses, with implications for immune evasion in chromosomally unstable cancers.

Cell Reports · Aug 1, 2020Peer-reviewedMolecular Biology