Zinc availability in the tumor microenvironment dictates anti-PD1 response in CDKN2ALow tumors via increased macrophage phagocytosis
Raquel Buj, Aidan R. Cole, Jeff Danielson, Jimmy P. Xu, Drew E. Hurd, Akash Kishore, Katarzyna M. Kedziora, Jie Chen, Baixue Yang, David Barras, Apoorva Uboveja, Amandine Amalric, Juan J Apiz Saab, Jayamanna M. Wickramasinghe, Naveen Kumar Tangudu, , Katherine M. Aird
This study shows that zinc availability in the tumor microenvironment affects anti-PD1 therapy response in CDKN2A-low tumors through macrophage phagocytosis.
bioRxiv · Feb 8, 2025 · PreprintCancer Biology