Nicola Gritti

Self-organization of vascularized skeletal muscle from bovine embryonic stem cells

This study induces skeletal muscle, neuronal, and endothelial cells from bovine embryonic stem cells and demonstrates their self-organization into vascularized tissue structures.

Metabolic control of germ layer proportions through regulation of Nodal and Wnt signalling

The paper shows that glycolytic activity regulates germ layer proportions by modulating Nodal and Wnt signalling in mouse gastrulation.

Axial patterning of gastruloids via diverse cell type compositions

This study investigates how varying proportions of primed and naive ESCs affect gastruloid formation and AP axial patterning, revealing developmental flexibility in mammalian embryogenesis.

Desynchrony between events triggers a compensatory delay during C. elegans development

The paper shows that reduced insulin signaling in C. elegans delays cell divisions more than molting, increasing desynchrony and triggering a compensatory delay in the molting program.

Image restoration of degraded time-lapse microscopy data mediated by infrared-imaging.

This paper uses CNNs to restore deep-tissue contrast in GFP-based time-lapse imaging using infrared dye data, improving information content across developmental stages.

Dynamics of anteroposterior axis establishment in a mammalian embryo-like system

The paper studies AP axis establishment in gastruloids using scRNA-seq and identifies molecular signatures of germ layer commitment and differences between Bra/T+ and Bra/T- populations.

Random birth order and bursty Notch ligand expression drive the stochastic AC/VU cell fate decision in C. elegans

The paper investigates how molecular noise and birth order influence the stochastic AC/VU cell fate decision in C. elegans using time-lapse microscopy and single molecule FISH.