Pablo Bora

Probing RNA-protein interactions in the early mouse embryo

The paper adapts REMORA to study RNA-binding protein functions in early mouse embryos, identifying direct regulatory roles for several RBPs, including Alyref in 3' polyadenylation control.

Spatial positioning of preimplantation mouse embryo blastomeres is regulated by mTORC1 and 7mG-cap dependent translation at the 8- to 16-cell transition.

The paper identifies mTORC1 and 7mG-cap dependent translation as regulators of spatial positioning of blastomeres during the 8- to 16-cell transition in mouse embryos.

DDX21 is a p38-MAPK sensitive nucleolar protein necessary for mouse preimplantation embryo development and cell-fate specification.

This study investigates the role of DDX21 in mouse preimplantation embryo development, showing its necessity for cell-fate specification and blastocyst formation through p38-MAPK regulation.

p38-MAPK mediated rRNA processing and translation regulation enables PrE differentiation during mouse blastocyst maturation.

This study shows that p38-MAPK regulates PrE differentiation during mouse blastocyst maturation by controlling translation and rRNA processing through Mybpp1a.

Wwc2 is a novel cell division regulator during preimplantation mouse embryo lineage formation and oogenesis

This study identifies Wwc2 as a regulator of cell division during mouse preimplantation embryo development and oogenesis, showing its role in maintaining cell number and division fidelity.

p38-mitogen activated kinases mediate a developmental regulatory response to amino acid depletion and associated oxidative stress in mouse blastocyst embryos

The paper shows that p38-MAPK regulates blastocyst development in response to amino acid availability and oxidative stress, affecting cell lineage specification and blastocyst size.