Lenka Gahurová

Decoding the naked mole-rat genome, telomere to telomere

The paper presents a telomere-to-telomere genome assembly of the naked mole-rat and compares it with a related species to identify gene losses and duplications associated with unique traits.

TEAD4 regulates apical domain homeostasis and cell-positioning to maintain the trophectoderm lineage during preimplantation mouse embryo development.

This study shows TEAD4 maintains trophectoderm lineage integrity by regulating apical domain morphology and cell positioning in mouse preimplantation embryos.

PRC2 facilitates the transition from heterotrophy to photoautotrophy during seedling emergence

This study identifies two phases of PRC2-mediated gene repression during seedling emergence, linking PRC2 activity to metabolic and developmental transitions from heterotrophy to photoautotrophy.

Spatial positioning of preimplantation mouse embryo blastomeres is regulated by mTORC1 and 7mG-cap dependent translation at the 8- to 16-cell transition.

The paper identifies mTORC1 and 7mG-cap dependent translation as regulators of spatial positioning of blastomeres during the 8- to 16-cell transition in mouse embryos.

DDX21 is a p38-MAPK sensitive nucleolar protein necessary for mouse preimplantation embryo development and cell-fate specification.

This study investigates the role of DDX21 in mouse preimplantation embryo development, showing its necessity for cell-fate specification and blastocyst formation through p38-MAPK regulation.

p38-MAPK mediated rRNA processing and translation regulation enables PrE differentiation during mouse blastocyst maturation.

This study shows that p38-MAPK regulates PrE differentiation during mouse blastocyst maturation by controlling translation and rRNA processing through Mybpp1a.

Wwc2 is a novel cell division regulator during preimplantation mouse embryo lineage formation and oogenesis

This study identifies Wwc2 as a regulator of cell division during mouse preimplantation embryo development and oogenesis, showing its role in maintaining cell number and division fidelity.