The paper introduces COMPASS, a method for sequence-independent imaging of glycoRNAs in living cells and tissues, revealing their distribution in cancer and neurogenesis.

Angewandte Chemie · Oct 28, 2026Peer-reviewedBioengineering

Bayesian inference of global land plant diversification dynamics across the Phanerozoic

Xiaoya Ma, Fabien L. Condamine, Yuxuan Zhao, Yutong Zhu, Xing Zhang, Yuanhao Li, Bojian Zhong

This study uses Bayesian methods to analyze land plant diversification dynamics across the Phanerozoic, identifying key patterns and drivers of diversification and extinction.

bioRxiv · Oct 2, 2026 · PreprintEvolutionary Biology

Quinoline-based compounds can inhibit diverse enzymes that act on DNA

Jujun Zhou, Qin Chen, Ren Ren, Jie Yang, Bigang Liu, John R. Horton, Caleb Chang, Chuxuan Li, Leora Maksoud, Yifei Yang, Dante Rotili, Abhinav K. Jain, Xing Zhang, Robert Blumenthal, Taiping Chen, , Xiaodong Cheng

This study identifies quinoline-based compounds that inhibit DNA methyltransferases and other DNA-targeting enzymes, with compound 11 inducing DNA damage response in cancer cells.

Cell chemical biology · Oct 21, 2024Peer-reviewedMolecular Biology

Dual Histone Methyl Reader ZCWPW1 Facilitates Repair of Meiotic Double Strand Breaks

Mohamed Mahgoub, Jacob Paiano, Melania Bruno, Wei Wu, Sarath Pathuri, Xing Zhang, Sherry Ralls, Xiaodong Cheng, André Nussenzweig, Todd S. Macfarlan

This study identifies ZCWPW1 as a dual histone methylation reader essential for meiotic DSB repair in vertebrates, showing its co-expression and co-evolution with PRDM9.

eLife · Apr 30, 2020Peer-reviewedGenetics