Seth W. Cheetham

This study develops mRNA-LNP therapy for MNGIE, restoring nucleoside balance and TP expression in mice through subcutaneous delivery.

This study shows that mRNA-LNPs can efficiently deliver mRNA to hepatocytes in healthy and diseased livers, including tumors, suggesting potential for systemic mRNA therapy in liver cancer.

This paper introduces a method using bispecific antibodies to deliver mRNA-LNPs to specific cell types, demonstrating efficient targeting of EGFR and PSMA positive cells.

mRNArchitect is a software toolkit for designing and optimising mRNA sequences to improve translation, stability, and immunogenicity, validated across multiple cell types and tissues.

The paper introduces Targeted DamID to detect cell-type specific histone modifications in vivo across different model organisms.

This study identifies HOPX as a molecular switch regulating cardiomyocyte progenitor and maturation gene programs, linking it to cardiac function and genetic variation.

This study introduces Nanopore-DamID, a method to detect DNA methylation and DNA-protein interactions, revealing methylation's role in transcription factor activity.

Methylartist provides tools for processing, visualizing, and analyzing nanopore methylation data, supporting multiple methylation types and enabling integrated study of modified bases.

This study identifies hundreds of novel transcribed pseudogenes using long-read sequencing and shows their functional relevance through translation and perturbation experiments.

This study identifies novel CHD8 genomic targets in fetal mouse brain using in vivo Targeted DamID, revealing binding sites related to neurodevelopment and autism-relevant biology.

This study uses nanopore sequencing and the TLDR tool to profile CpG methylation of transposable elements in human tissues and tumors.

This study investigates gene expression dynamics in mouse embryonic stem cells at high temporal resolution, revealing new insights into transcriptional regulation and noncoding RNA roles.