Author

Danielle M. Clancy

Ghent UniversityORCID 0000-0002-8700-3356Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Research Focus:cell signaling & trafficking· 1 Approach:comparative / phylogenetic analysis· 1 Assay:cryo-EM· 1 Research Focus:host-pathogen & immune response· 1 Organism:human· 1 Organism:mouse· 1 Research Focus:protein folding & dynamics· 1

Frequent Co-Authors

Jan FélixiD· 2 shared Savvas N. SavvidesiD· 2 shared Alba Sanz-Sanjuan· 1 shared Álvaro Furones Cuadrado· 1 shared Dirk Elewaut· 1 shared Elisabeth GilisiD· 1 shared Imke Velghe· 1 shared Janine D. BrunneriD· 1 shared

Activity by Year

2025-2025 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 33 mutual co-author links

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2 shared papersImmunology

Jan FélixORCID

Mutual co-authors in cluster

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2 papers

Recent·Most cited

Structural basis of pro-inflammatory signaling via the Interleukin-36 receptor (IL-36R) mediated by IL-36γ and IL-37

Julie Andries, Martin Toul, Jan Félix, Danielle M. Clancy, Savvas N. Savvides

This study reveals the structural mechanisms of IL-36R activation by IL-36γ and IL-37 and spesolimab's allosteric antagonism, providing a blueprint for therapeutic targeting.

bioRxiv · Feb 22, 2025 · PreprintImmunology

Themis and Grb2 form a constitutive structural hub in T cell receptor signalling

Danielle M. Clancy, Alba Sanz-Sanjuan, Elisabeth Gilis, Peter Tougaard, Imke Velghe, Yana Van Droogenbroeck, Jan Félix, Yehudi Bloch, Álvaro Furones Cuadrado, Romain Merceron, Stephan Schenck, Peter Vandenabeele, Janine D. Brunner, Tom Taghon, Dirk Elewaut, Savvas N. Savvides

This study determines the cryo-EM structure of the Themis-Grb2 complex, revealing its role as a dynamic structural hub in T cell receptor signaling and its functional importance in T cell development.

bioRxiv · Feb 16, 2025 · PreprintImmunology