Targeting SAGA/ATAC complexes disrupts chromatin regulation and cholesterol metabolism in diffuse midline glioma
Rosemary U. Richard, Caitlin L. Bagnetto, Rebecca L. Murdaugh, Brittany R Eberl, Alan L. Jiao, Adam Fiseha Kebede, Ena I. Campos-Hensley, Barry M. Zee, Margaret M. Harrington, Mariella G. Filbin, Akdes Serin Harmancı, Yang Shi, Jamie N. Anastas
This study shows that targeting SAGA/ATAC complexes disrupts chromatin regulation and cholesterol metabolism in diffuse midline glioma, leading to reduced tumor growth.
bioRxiv · Aug 17, 2026 · PreprintCancer Biology