Stephen J. Blanksby

Targeting de novo lipogenesis improves gemcitabine efficacy in pancreatic ductal adenocarcinoma

This study identifies de novo lipogenesis as a mechanism of gemcitabine resistance in PDAC and shows that targeting lipid synthesis enzymes enhances treatment efficacy.

Cis-vaccenic acid is a key product of stearoyl-CoA desaturase 1 and a critical oncogenic factor in prostate cancer

This study identifies cis-vaccenic acid as a critical oncogenic factor in prostate cancer, showing it rescues cell viability loss from SCD1 inhibition and promotes growth.

OzFAD: Ozone-enabled fatty acid discovery reveals unexpected diversity in the human lipidome

OzFAD uses ozonolysis with LC-MS to discover new unsaturated fatty acids in human samples, doubling identified plasma fatty acids and revealing non-canonical double bond positions.