Mark Ashe

This study shows that yeast Gcn2 promotes P-body formation through eIF2α phosphorylation and Smu2-dependent mRNA granule maturation, even when eIF2α phosphorylation is blocked.

The paper uses explainable AI on a genomic foundation model to identify RBP motifs influencing translation and mRNA decay in Drosophila.

The paper identifies suppressor variants that alter gene essentiality across yeast strains, revealing context-dependent genetic mechanisms.

This study shows that eIF3d's RNA-binding domain is essential for stress granule assembly in human cells and C. elegans, rescuing granule formation when expressed exogenously.

The paper develops AquIRE to quantify RNA damage and identifies multiple mechanisms of clinically induced RNA modifications, including glycoRNA dynamics across life kingdoms.

The paper uses the SunTag system to study mRNA translation regulation in Drosophila, showing leaky repression of maternal hb mRNA and demonstrating its use as a reporter for ribosome pausing and ER-localized translation.