Harold Cremer

In Vivo AGO-APP For Cell-Type- and Compartment-Specific miRNA Profiling in the Mouse Brain

The paper introduces a method to profile miRNA expression in specific cell types and compartments in the mouse brain using transgenic mice and validates its effectiveness through bioinformatic analysis.

Integrated 3D Light-Sheet and 2D Multiplex Imaging for Deep Histological Profiling of a Somatic Mouse Glioblastoma Model

The paper presents a somatic glioblastoma mouse model characterized using 3D light-sheet and 2D multiplex imaging to enable deep histological profiling and spatial analysis of tumor proteomes.

Gliogenesis from the subventricular zone modulates the extracellular matrix at the glial scar after brain ischemia

The paper identifies Thbs4-positive astrocytes from the SVZ that modulate the extracellular matrix at the glial scar after brain ischemia by synthesizing and degrading hyaluronan.

Dynamic intraglomerular neuronal ensembles represent odor identity and concentration

The paper identifies intraglomerular neuronal ensembles in the olfactory bulb that encode both odor identity and concentration.

In vivo AGO-APP identifies a module of microRNAs cooperatively controlling exit from neural stem cell state

The paper introduces AGO-APP to isolate active miRNAs from Drosophila neural cells, identifies a miRNA module controlling neuroblast to neuron transition, and shows their cooperative function.

Sensory deprivation triggers phenotypic adjustment of dopaminergic interneurons in the mouse olfactory bulb

The paper shows that sensory deprivation causes GABAergic interneurons to die while dopaminergic neurons adapt by reducing tyrosine hydroxylase expression in mice.

Intrinsic neuronal activity during migration controls the recruitment of specific interneuron subtypes in the postnatal mouse olfactory bulb

The paper investigates how intrinsic neuronal activity during migration affects the recruitment of specific interneuron subtypes in the postnatal mouse olfactory bulb, finding that activity is critical for granule cell precursor migration and positioning but not for periglomerular neuron precursors.

Regulatory interactions between Vax1, Pax6, and miR-7 regionalize the lateral Ventricular-Subventricular Zone during post-natal Olfactory Bulb neurogenesis in mice

The paper identifies Vax1's role in regulating neuronal subtype production in the olfactory bulb by repressing Pax6 via miR-7, influencing positional identity of neural stem cells.

Disruption of the transcription factor NEUROD2 causes an autism syndrome via cell-autonomous defects in cortical projection neurons

This study identifies NEUROD2 mutations linked to ASD and intellectual disability, showing their role in cortical development and function through mouse models.

Neuronal integration in the adult olfactory bulb is a non-selective addition process

This study uses 2-photon imaging to show that neuronal integration in the adult olfactory bulb occurs without cell loss and without a critical period, challenging the turnover model.