Gunter Meister

In Vivo AGO-APP For Cell-Type- and Compartment-Specific miRNA Profiling in the Mouse Brain

The paper introduces a method to profile miRNA expression in specific cell types and compartments in the mouse brain using transgenic mice and validates its effectiveness through bioinformatic analysis.

Pachytene piRNAs define a conserved program of meiotic gene regulation

The paper identifies pachytene piRNAs as precise gene regulators during meiosis, showing they target specific mRNAs through near-perfect complementarity.

In vivo AGO-APP identifies a module of microRNAs cooperatively controlling exit from neural stem cell state

The paper introduces AGO-APP to isolate active miRNAs from Drosophila neural cells, identifies a miRNA module controlling neuroblast to neuron transition, and shows their cooperative function.

A rapid protocol for ribosome profiling of low input samples

This paper introduces a rapid ribosome profiling protocol for low-input samples, reducing RNA input to 0.1 pmol and enabling high-quality data from small samples.

Inducible and reversible inhibition of miRNA-mediated gene repression in vivo

This study develops a genetic tool to reversibly inhibit miRNA-mediated gene repression in vivo and shows tissue-specific dependencies on miRNA function for homeostasis and regeneration.

Low miRNA abundance disables microRNA pathway in mammalian oocytes

The paper shows that low miRNA abundance in mammalian oocytes disables the miRNA pathway, as demonstrated by functional assays and cross-species analysis.

LIN28 selectively modulates a subclass of let-7 microRNAs

The paper identifies a GAU motif recognized by LIN28's CSD domain, which enhances let-7 microRNA suppression in Class I precursors, contributing to development and cancer.