Polyglutamine-expanded TBP rewires neuronal and muscle proteomes beyond transcription in a Drosophila model of SCA17
Matthew V. Prifti, Kristin Richardson, Fatimah H Hussein, Truman Kula, Anna Stephan, Yong-Dong Wang, Wei Wang, Anthony A. High, Suresh Poudel, Fabio Demontis, Sokol V. Todi
This study identifies tissue-specific proteomic changes in a Drosophila SCA17 model, showing polyglutamine-expanded TBP affects pathways beyond transcription.
bioRxiv · Oct 21, 2026 · PreprintNeuroscience