Sotiris C. Masmanidis

Learning dynamically regulates stimulus discrimination of ventral striatal D1 receptor expressing neurons

This study shows that D1 medium spiny neurons in the ventral striatum show increased selectivity for reward-paired cues during learning, while D2 neurons show less change, indicating a dynamic role for D1 neurons in stimulus discrimination.

Complementary cortical and striatal encoding of locomotor preparation and performance

This study compares how cortical and striatal regions encode locomotor preparation and performance in mice, finding complementary coding schemes in different brain areas.

Dopamine lesions alter the striatal encoding of single-limb gait

This study shows that dopamine depletion in mice alters striatal neuron phase-locking to individual limb gait cycles, suggesting a role for D2 MSNs in gait impairments.

Correlated signatures of social behavior in cerebellum and anterior cingulate cortex

The paper develops E-Scope, a tool for simultaneous multimodal recordings in freely behaving mice, revealing cerebellar and ACC activity patterns during social behavior.

Physiological constraints on the rapid dopaminergic modulation of striatal reward activity

This study investigates the rapid effects of dopaminergic modulation on striatal spiking activity and finds that physiological DA levels do not strongly influence spiking, except when DA exceeds reward-matched levels.

Encoding time in neural dynamic regimes with distinct computational tradeoffs

This paper trains RNNs on timing tasks to investigate how neural dynamics encode time with different computational tradeoffs and generalization capabilities.

Inhibition-Dominated Rich-Club Shapes Dynamics in Cortical Microcircuits

The paper shows that inhibitory neurons dominate the rich-club structure in cortical microcircuits, influencing network dynamics through increased synchrony and longer neuronal avalanches.

DOWN state in the anterior cingulate and prelimbic areas in rats during immobility.

The paper analyzes the DOWN state in rats during immobility, showing local and generalized slow oscillations in prefrontal cortex and hippocampus with distinct neuronal correlates.

Reduced prefrontal synaptic connectivity and disturbed oscillatory population dynamics in the CNTNAP2 model of autism

This study investigates the effects of CNTNAP2 loss-of-function mutations in mice, finding reduced synaptic connectivity and altered oscillatory dynamics in the prefrontal cortex associated with autism-like behaviors.

Breakdown of spatial coding and neural synchronization in epilepsy

This study investigates spatial coding and neural synchronization in epilepsy using in vivo calcium imaging and network modeling, finding impaired spatial processing and desynchronized firing in epileptic mice.