Author

Michael Lucas James

Duke UniversityORCID 0000-0002-8715-5210Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Neuroscience· 2 Genetic & Genomic Medicine· 1

Signature Assays, Organisms & Methods

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Research Focus:differential expression· 2 Approach:experimental assay· 2 Organism:human· 2 Organism:mouse· 2 Approach:Bayesian inference· 1 Research Focus:cell type annotation· 1 Research Focus:drug response / drug discovery· 1 Research Focus:gene regulatory network inference· 1

Frequent Co-Authors

Bradford B. WorralliD· 1 shared Çağla EroğluiD· 1 shared Carl D. LangefeldiD· 1 shared Christiana E. Hall· 1 shared Christopher D. AndersoniD· 1 shared Christopher D. LascolaiD· 1 shared Daniel T. LaskowitziD· 1 shared Daniel WooiD· 1 shared

Activity by Year

2021-2023 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 22 mutual co-author links

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1 shared paperGenetic & Genomic Medicine

Bradford B. WorrallORCID

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3 papers

Recent·Most cited

Deep resequencing of the 1q22 locus in non-lobar intracerebral hemorrhage

Livia Parodi, Mary E. Comeau, Marios K. Georgakis, Ernst Mayerhofer, Jaeyoon Chung, Guido J. Falcone, Rainer Malik, Stacie L Demel, Bradford B. Worrall, Sebastian Koch, Fernando Daniel Testai, Steven J. Kittner, Jacob L. McCauley, Christiana E. Hall, Douglas J. Mayson, , Christopher D. Anderson

The paper performs deep resequencing of the 1q22 locus in non-lobar ICH cases and controls to identify causal variants and mechanisms.

Annals of Neurology · Oct 4, 2023Peer-reviewedGenetic & Genomic Medicine

Sparcl1/Hevin drives inflammatory and neuropathic pain through astrocyte and NMDA receptor signaling

Gang Chen, Hao Luo, Xin Luo, Sandeep K. Singh, Juan J. Ramirez, Michael Lucas James, Joseph P. Mathew, Miles Berger, Çağla Eroğlu, Ru‐Rong Ji

This study shows hevin, an astrocyte-secreted protein, maintains chronic pain through NMDA receptor signaling, and neutralizing hevin may offer new therapeutic strategies for pain and neurodegeneration.

bioRxiv · Mar 28, 2022 · PreprintNeuroscience

Neuroprotective pentapeptide, CN-105, improves outcomes in translational models of intracerebral hemorrhage

Haichen Wang, Timothy D. Faw, Yufeng Lin, Shan Huang, Talaignair N. Venkatraman, Viviana Cantillana, Christopher D. Lascola, Michael Lucas James, Daniel T. Laskowitz

This study shows that the pentapeptide CN-105 improves outcomes in multiple translational intracerebral hemorrhage models across different species, sexes, and ages.

Neurocritical Care · Jan 20, 2021Peer-reviewedNeuroscience