Author

Felipe de Sousa e Melo

Amgen (United States)ORCID 0000-0002-9558-3098Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Research Focus:drug response / drug discovery· 2 Approach:experimental assay· 2 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell signaling & trafficking· 1 Organism:mouse· 1 Research Focus:protein folding & dynamics· 1 Assay:spatial transcriptomics· 1

Frequent Co-Authors

Amy S. Chuong· 1 shared Ana M. MeirelesiD· 1 shared Anh T. Tran· 1 shared Antonio RiosiD· 1 shared Arghya Sadhukhan· 1 shared Aviv RegeviD· 1 shared Avtar K SinghiD· 1 shared Bo LiiD· 1 shared

Activity by Year

2024-2025 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 24 mutual co-author links

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1 shared paperSystems Biology

Amy S. Chuong

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2 papers

Recent·Most cited

LYMTACs: Chimeric Small Molecules Repurpose Lysosomal Membrane Proteins for Target Protein Relocalization and Degradation

Dhanusha A. Nalawansha, Georgios Mazis, Gitte Husemoen, Kate S. Ashton, Weixian Deng, Ryan P. Wurz, Anh T. Tran, Brian A. Lanman, Jiansong Xie, Robert G. Guenette, Shiqian Li, Christopher E. Smith, Suresh Archunan, Manoj K. Agnihotram, Arghya Sadhukhan, , Patrick Ryan Potts

This paper introduces LYMTACs, small molecules that use lysosomal membrane proteins to target and degrade membrane proteins, showing effectiveness against KRASG12D.

Nature Communications · Aug 21, 2025Peer-reviewedCancer Biology

Highly multiplexed, image-based pooled screens in primary cells and tissues with PerturbView

Takamasa Kudo, Ana M. Meireles, Reuben M. Moncada, Yushu Chen, Ping Wu, Joshua Gould, Xiao‐Yu Hu, Opher S. Kornfeld, Rajiv Jesudason, Conrad Foo, Burkhard Höckendorf, Héctor Corrada Bravo, Jason P. Town, Runmin Wei, Antonio Rios, , Eric Lubeck

PerturbView enables highly multiplexed optical pooled screens in primary cells and tissues by improving barcode amplification, revealing regulators of NFκB signaling and enabling spatial transcriptomics integration.

Nature Biotechnology · Oct 7, 2024Peer-reviewedSystems Biology