Elodie Chabrol

LGI1 downregulation increases neuronal circuit excitability

This study shows that reducing LGI1 levels increases neuronal excitability and synaptic plasticity, potentially contributing to epilepsy and limbic encephalitis.

Epilepsy gene therapy using non-integrating lentiviral delivery of an engineered potassium channel gene

This paper develops a non-integrating lentiviral gene therapy for refractory focal epilepsy, showing reduced seizure frequency in a rat model.

Semiology, clustering, periodicity and natural history of seizures in an experimental visual cortical epilepsy model

This paper characterizes a rat model of focal neocortical epilepsy induced by tetanus toxin injection, showing seizure clustering, circadian variation, and predictive seizure counts.