Daniel J. Klionsky

Genome-wide analysis reveals the importance of histone acetyltransferase Esa1 in transcriptional regulation during nitrogen starvation

The paper investigates transcriptional changes and chromatin modifications during nitrogen starvation, showing Esa1's role in gene activation through histone acetylation.

Bi-allelic ATG12 variants impair autophagy and cause a neurodevelopmental disorder

The paper identifies bi-allelic ATG12 variants causing a neurodevelopmental disorder by impairing autophagy, with clinical and functional evidence from patient cells, yeast, and zebrafish models.

Sex and Region-Specific Disruption of Autophagy and Mitophagy in Alzheimer's Disease: Linking Cellular Dysfunction to Cognitive Decline

This study examines sex-specific differences in autophagy and mitophagy in Alzheimer's disease using mouse models and machine learning to predict cellular outcomes.

TgATG9 is required for autophagosome biogenesis and maintenance of chronic infection in Toxoplasma gondii

This study identifies TgATG9 as essential for autophagosome formation and chronic Toxoplasma gondii infection.

Unlocking a New Path: An Autophagometer that Measures Flux Using a Non-Fluorescent Immunohistochemistry Method

This paper introduces a non-fluorescent immunohistochemistry method to measure autophagy flux, demonstrating its cost-effectiveness and applicability to clinical settings.

Intracellular level of S. cerevisiae Rad51 is regulated via proteolysis in a SUMO- and Ubiquitin-dependent manner

The paper investigates how the intracellular level of Rad51 in S. cerevisiae is regulated through proteolysis involving SUMO and ubiquitin modifications.

The human disease gene CLEC16A encodes an intrinsically disordered protein region required for mitochondrial quality control

This study identifies an intrinsically disordered protein region in CLEC16A critical for mitochondrial quality control and diabetes prevention.