Author

Marc Creixell

Koch Institute for Integrative Cancer Research At MITORCID 0000-0002-6013-6546Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Biochemistry· 1 Bioinformatics· 1 Immunology· 1 Systems Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Approach:statistical model· 3 Research Focus:host-pathogen & immune response· 2 Organism:human· 2 Organism:mouse· 2 Assay:proteomics· 2 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell type annotation· 1

Frequent Co-Authors

Michael B. YaffeiD· 2 shared Pau CreixelliD· 2 shared Aaron S. MeyeriD· 1 shared Aaron W. StebbinsiD· 1 shared Alexis R. BarriD· 1 shared Antonio PalmeriiD· 1 shared Bert van de KooijiD· 1 shared Brian A. JoughiniD· 1 shared

Activity by Year

2018-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 23 mutual co-author links

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2 shared papersBiochemistry

Michael B. YaffeORCID

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

PTPN1/2 inhibits alveolar macrophage-mediated control of lung metastasis

Yue Liu, Im-Meng Sun, Marc Creixell, Jordan Brown, Samir Kharbanda, James J. Lee, Varahram Shahryari, Kayley Hake, Jacqueline O'Hara, Kenneth J. Finn, Nianxin Yang, Lolita Penland, Jiaxi Wang, Ka Man Li, John Balibalos, , Jonathan D. Powell

This study shows that inhibiting PTPN1/2 enhances alveolar macrophage anti-metastatic activity through IFN-gamma-STAT1 signaling, offering a therapeutic strategy for metastasis.

bioRxiv · Feb 26, 2026 · PreprintImmunology

Structural Identification of Major Molecular Determinants for Phosphotyrosine Recognition in Tyrosine Kinases Reveals Tumour Promoting and Suppressive Functions

Nuo Cheng, Luis R. Millán-Barea, Marc Creixell, Alexis R. Barr, Yi Wen Kong, Brian A. Joughin, Cécile K. Lopez, Jette Lengefeld, James Clarke, Chuan Liu, Ganapathy Sriram, Tania J González-Robles, Bert van de Kooij, Simonas Savickas, Erwin M. Schoof, , Michael B. Yaffe

The paper identifies molecular determinants for phosphotyrosine recognition in tyrosine kinases and shows their roles in tumor promotion and suppression.

bioRxiv · Jun 10, 2025 · PreprintBiochemistry

Motif-based phosphoproteome clustering improves modeling and interpretation

Marc Creixell, Aaron S. Meyer

The paper introduces DDMC, a clustering strategy for phosphoproteomic data that groups phosphopeptides by phosphorylation abundance and sequence motifs, improving modeling and interpretation of kinase signaling in lung cancer.

Cell Reports Methods · Feb 1, 2022Peer-reviewedBioinformatics

Hierarchical organization endows the kinase domain with regulatory plasticity

Pau Creixell, Jai Prakash Pandey, Antonio Palmeri, Moitrayee Bhattacharyya, Marc Creixell, Rama Ranganathan, David Pincus, Michael B. Yaffe

This study reveals a hierarchical organization in the kinase domain that enables regulatory plasticity through distinct functional units.

Cell Systems · Sep 19, 2018Peer-reviewedSystems Biology