Youngho Kwon

BRCA1 promotes homologous recombination through separable DNA and RAD51 binding activities within its disordered region.

This study identifies DNA binding and RAD51 interaction interfaces in BRCA1's disordered region and shows their distinct roles in homologous recombination and DNA repair.

Phosphoregulation of RAD51AP1 function in homology-directed repair

This study shows that phosphorylation of RAD51AP1 at S277/282 regulates its function in homology-directed DNA repair, with phosphomimetic variants enhancing its activity.

Distinct roles of the two BRCA2 DNA binding domains in DNA damage repair and replication fork preservation

This study identifies distinct roles of BRCA2's two DNA binding domains in DNA repair and replication fork stability using genetic and biochemical methods.

TLK1-mediated RAD54 phosphorylation spatio-temporally regulates Homologous Recombination Repair

This study identifies TLK1-mediated phosphorylation of RAD54 at specific sites that regulate homologous recombination repair, with distinct effects on repair efficiency and cell survival.