Robrecht Raedt

Seizure control via astrocyte targeted optogenetic extracellular potassium modulation: computational analysis of K+ vs non-selective cation-conducting opsins

This paper compares potassium-selective and non-selective opsins for astrocyte-targeted extracellular potassium modulation, finding that potassium-selective opsins are more effective in reducing [K+]e.

A photoswitchable cannabinoid for precision treatment of refractory seizures in a mouse epilepsy model

The paper demonstrates the use of a photoswitchable cannabinoid, azo-THC-3, to suppress seizures in a mouse model by local photoactivation in the hippocampus, avoiding systemic side effects.

Computational analysis of optogenetic inhibition of CA1 neurons using a data-efficient and interpretable potassium and chloride conducting opsin model

This study develops a data-efficient and interpretable model of optogenetic inhibition using potassium and chloride opsins to analyze how parameters and physiological conditions affect seizure suppression in CA1 neurons.

tDCS Cranial Nerve Co-Stimulation: Unveiling Brainstem Pathways Involved in Trigeminal Nerve Direct Current Stimulation in Rats

This study investigates how trigeminal nerve direct current stimulation (TN-DCS) affects brainstem neuronal activity in rats, finding significant modulation in locus coeruleus and dorsal raphe nucleus but not median raphe nucleus.

Photopharmacological activation of adenosine A1receptor signaling suppresses seizures in a mousemodel for temporal lobe epilepsy

This study demonstrates that photopharmacological activation of A1R reduces seizures in a mouse model of temporal lobe epilepsy with fewer side effects than systemic administration.

Feedback Control of Neuronal Excitability and Epileptiform Bursting using a Photocaged Adenosine A1 Agonist

This study uses a photocaged adenosine A1 agonist in a closed-loop system to control neuronal excitability and suppress epileptiform bursting in hippocampal slices.

Quantitative Analysis of the Optogenetic Excitability of CA1 Neurons

This study uses computational models to analyze optogenetic excitability in CA1 neurons and identifies strategies to improve stimulation protocols.

Modulation of locus coeruleus neurons and strong release of noradrenaline during acute hippocampal seizures in rats