Author

Patrick Pfaff

Howard Hughes Medical InstituteORCID 0000-0002-9761-2497Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Cancer Biology· 1 Microbiology· 1 Neuroscience· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Research Focus:drug response / drug discovery· 2 Assay:proteomics· 2 Approach:biophysical modeling· 1 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell signaling & trafficking· 1 Research Focus:host-pathogen & immune response· 1 Organism:human· 1

Frequent Co-Authors

Kevan M. ShokatiD· 2 shared Bilal KiciniD· 1 shared Carina De Rijck· 1 shared Dimitri De BundeliD· 1 shared Douglas R. WassarmaniD· 1 shared Erick M. CarreiraiD· 1 shared Evelien HendrixiD· 1 shared Gino De SmetiD· 1 shared

Activity by Year

2025-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 24 mutual co-author links

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2 shared papersCancer Biology

Kevan M. ShokatORCID

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3 papers

Recent·Most cited

A photoswitchable cannabinoid for precision treatment of refractory seizures in a mouse epilepsy model

Sofie S. Bournons, Miroslav Kosar, Bilal Kicin, Roman C. Sarott, Evelien Hendrix, Rudolf L. Z. Ganzoni, Patrick Pfaff, Tristano C. Martini, Matthias V. Westphal, Michael A. Schafroth, Gino De Smet, Carina De Rijck, Liam Nestor, Robrecht Raedt, Erick M. Carreira, , Ilse Julia Smolders

The paper demonstrates the use of a photoswitchable cannabinoid, azo-THC-3, to suppress seizures in a mouse model by local photoactivation in the hippocampus, avoiding systemic side effects.

bioRxiv · May 7, 2026 · PreprintNeuroscience

GAP mimetic activity of pan-Ras TCI daraxonrasib synergizes with K-Ras Switch-II pocket inhibition

Patrick Pfaff, Kevan M. Shokat

This paper shows that daraxonrasib, a pan-Ras TCI, acts as a GAP mimic and synergizes with K-Ras Switch-II inhibitors to enhance pathway suppression and reduce toxicity.

Biological Chemistry · Apr 17, 2026Peer-reviewedCancer Biology

Deazaguanylation is a nucleobase-protein conjugation required for type IV CBASS immunity

Douglas R. Wassarman, Patrick Pfaff, João A. Paulo, Steven P. Gygi, Kevan M. Shokat, Philip J. Kranzusch

The paper identifies 7-deazapurine protein conjugation as essential for type IV CBASS immunity, revealing the roles of Cap9 and Cap10 in this process.

Science · Sep 25, 2025Peer-reviewedMicrobiology