Tom J. Little

Increased stress in early life epigenetically rewires pathways related to aging and longevity

This study shows that early-life stress accelerates epigenetic aging in zebra finches by altering DNA methylation and metabolic pathways linked to aging.

Optimal virulence in ageing populations

The paper models how population ageing affects optimal pathogen virulence for four diseases in different regions, finding increased virulence in some areas and decreased in others.

Epigenetic Clocks Uncover the Natural History of Ageing in Wild Mice

This paper develops an epigenetic clock for wild wood mice to estimate age and ageing rates, showing slower ageing in supplemented and parasite-treated individuals.

Reducing food stress and parasitism may have unexpected consequences on faecal corticosterone in a wild rodent

This study examines how manipulating food availability and parasite burden affects faecal corticosterone levels in wood mice, finding no direct impact but suggesting potential indirect effects.

Epigenetic age estimation of wild mice using faecal samples

This paper develops an epigenetic clock using faecal DNA from lab mice to estimate age in wild mice, finding higher methylation and epigenetic age in wild mice compared to lab mice.

Universal DNA methylation age across mammalian tissues

The paper develops universal epigenetic clocks that accurately estimate age across mammalian tissues using DNA methylation data from 185 species.

Daphnia magna egg piRNA cluster expression profiles change as mothers age.

The paper identifies piRNA-producing clusters in Daphnia magna and shows their expression changes with maternal age, affecting germline piRNA profiles and potentially impacting genome stability.

Daphnia magna modifies its gene expression extensively in response to caloric restriction revealing a novel effect on haemoglobin isoform preference

This study shows that caloric restriction in Daphnia magna causes extensive gene expression changes, including a shift in haemoglobin isoform preference, similar to hypoxia responses.

Methylation-Based Age Estimation in a Wild Mouse

This paper develops an epigenetic clock for wild wood mice using DNA methylation data to estimate age and study ageing rates in the wild.

Genome-wide Methylation Patterns Under Caloric Restriction in Daphnia magna.

This study examines DNA methylation changes in Daphnia magna under caloric restriction, identifying differentially methylated regions and their functional implications.