Author

David F. Lee

Harvard UniversityORCID 0000-0002-8961-3115Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Organism:mouse· 3 Research Focus:differential expression· 2 Research Focus:gene regulatory network inference· 2 Organism:human· 2 Assay:scRNA-seq· 2 Approach:statistical model· 2 Assay:ATAC-seq· 1

Frequent Co-Authors

Alec R. ChapmaniD· 2 shared Wenjie Sun· 2 shared Wenping MaiD· 2 shared Xiang LiiD· 2 shared Xiaoliang Sunney XieiD· 2 shared Ayjan Semayel· 1 shared Christiann H. GainesiD· 1 shared Darla R. MilleriD· 1 shared

Activity by Year

2019-2022 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 29 mutual co-author links

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2 shared papersGenomics

Alec R. ChapmanORCID

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

The open field assay is influenced by room temperature and by drugs that affect core body temperature

Jessica A. Jiménez, Eric S. McCoy, David F. Lee, Mark J. Zylka

This study shows that ambient and core body temperature affect open field assay results in mice, with TRPM8 channel activity modulating these effects.

bioRxiv · Oct 17, 2022 · PreprintNeuroscience

Cocaine-induced locomotor activation differs across six sets of inbred mouse substrains

Christiann H. Gaines, Sarah Adams Schoenrock, Joseph Farrington, David F. Lee, Lucas J. Aponte‐Collazo, Ginger D. Shaw, Darla R. Miller, Martin T. Ferris, Fernando Pardo‐Manuel de Villena, Lisa M. Tarantino

The paper assesses cocaine-induced locomotor activation in 20 inbred mouse substrains from six lineages, identifying significant phenotypic differences that could inform genetic studies of addiction.

bioRxiv · Nov 8, 2021 · PreprintGenetics

Genomic Architecture of Cells in Tissues (GeACT): Study of Human Mid-gestation Fetus

Feng Tian, Fan Zhou, Xiang Li, Wenping Ma, Honggui Wu, Ming Yang, Alec R. Chapman, David F. Lee, Longzhi Tan, Dong Xing, Guangjun Yin, Ayjan Semayel, Jing Wang, Jia Wang, Wenjie Sun, , Xiaoliang Sunney Xie

The paper introduces GeACT, a genomic database for human mid-gestation fetus cells, linking gene expression to chromatin states and identifying key transcription factors.

bioRxiv · Apr 12, 2020 · PreprintGenomics

Correlated Gene Modules Uncovered by Single-Cell Transcriptomics with High Detectability and Accuracy

Alec R. Chapman, David F. Lee, Wenting Cai, Wenping Ma, Xiang Li, Wenjie Sun, Xiaoliang Sunney Xie

The paper identifies correlated gene modules using single-cell RNA-seq, revealing biological functions and regulatory relationships through covariance analysis.

bioRxiv · Dec 31, 2019 · PreprintGenomics