This study shows that stroke increases hippocampal neurogenesis but leads to maladaptive morphological features in newborn neurons across multiple mouse stroke models.

Stroke · Jul 16, 2026Peer-reviewedAnimal Behavior & Cognition

Assessing post-stroke cognition in pre-clinical models: lessons and recommendations from a multi-center study

Gaia Brezzo, Kristy A. Zera, Dana Straus, Jennifer E. Goertz, Sanna H. Loppi, R. Crumpacker, Jennifer Beischel Frye, Danielle A. Becktel, María Isabel Cuartero, Alicia García‐Culebras, Claudia Dames, Daniel Berchtold, Jill H. Fowler, Andreas Meisel, Josef Anrather, , Barry W. McColl

This study evaluates cognitive outcomes after stroke in mice using multiple models and tests, finding inconsistent results and highlighting challenges in pre-clinical stroke cognition research.

Journal of Cerebral Blood Flow & Metabolism · Dec 7, 2025Peer-reviewedAnimal Behavior & Cognition

A primeval mechanism of tolerance to desiccation based on glycolic acid saves neurons from ischemia in mammals by reducing intracellular calcium-mediated excitotoxicity

Alexandra Chovsepian, Daniel Berchtold, Katarzyna Winek, Uta Mamrak, Inés Ramírez Álvarez, Yanina Dening, Dominika Gołubczyk, Luis Weitbrecht, Claudia Dames, Marine Aillery, Celia Fernández‐Sanz, Zdzisław Gajewski, Marianne Dieterich, Mirosław Janowski, Peter Falkai, , Francisco J. Pan-Montojo

This study shows that glycolic acid protects neurons from ischemic damage by reducing calcium-mediated excitotoxicity during reperfusion in stroke models.

Advanced Science · Dec 14, 2021Peer-reviewedNeuroscience