Sachiko Murase

Visual deprivation in adulthood engages presynaptic plasticity of thalamocortical synapses

This study shows that adult mice can exhibit reversible presynaptic plasticity at thalamocortical synapses through visual deprivation and light reintroduction.

Prolonged visual deprivation in adults induces non-homeostatic plasticity of feed-forward excitation from visual thalamus to cortex

This study shows that prolonged visual deprivation in adult mice induces reversible, non-homeostatic plasticity at thalamocortical synapses in layer 4 pyramidal neurons.

All-or-none disconnection of pyramidal inputs onto parvalbumin-positive interneurons gates ocular dominance plasticity

The paper shows that monocular deprivation in mouse visual cortex causes an all-or-none elimination of pyramidal cell connections to parvalbumin-positive interneurons, which is necessary for ocular dominance plasticity.

Homeostatic regulation of perisynaptic MMP9 activity in the amblyopic visual cortex

This study shows that LRx in amblyopic mice induces MMP2/9 activity and ECM degradation in V1, enabling synaptic plasticity through homeostatic regulation of proteolysis.

Regulation of expression site and generalizability of experience-dependent plasticity in visual cortex

This study investigates how different visual stimulation frequencies affect the site and generalizability of experience-dependent plasticity in mouse visual cortex.