Robert G. Parton

Apical-Out Ileal Organoids: A Versatile Platform for Probing Gut-Nanomaterial Interactions

This study establishes human apical-out ileal organoids as a model to study gut-nanomaterial interactions, showing charge-selective uptake regulated by the glycocalyx.

Mural cells protect the adult brain from hemorrhage but do not control the blood-brain barrier in developing zebrafish

This study shows that mural cells are not required for BBB function in developing zebrafish but protect against hemorrhage-induced BBB breakdown in adults.

Cardiomyocyte caveolae govern myocardial function and sex-dependent regulation of ventricular compliance and resilience via cavin-1

This study investigates the role of cardiomyocyte caveolae and cavin-1 in myocardial function, revealing sex-dependent effects on ventricular compliance and resilience through mechanisms involving NOS signaling and fibrosis.

Defensive lipid droplets are PUFA reservoirs driving bacterial clearance and inflammation

The paper shows that lipid droplets store polyunsaturated fatty acids (PUFAs) that are critical for bacterial clearance and inflammation by macrophages.

Membrane contacts between caveolae and the endoplasmic reticulum regulate uptake and metabolic trapping of long-chain fatty acids

The paper investigates how caveolae and ER membrane contacts regulate LCFA uptake and metabolic trapping, showing FATP1 and caveolin1's role in coupling these processes.

A modular encapsulation system for precision delivery of proteins, nucleic acids and small molecules

This paper introduces caveospheres, a modular nanovesicle system for targeted delivery of various cargo, demonstrating efficacy in both in vitro and in vivo applications.

Integrin β1-Talin1 at focal adhesions underpin uncontrolled endothelial cell enlargement in live cerebral cavernous malformation vasculature

This study shows integrin β1-Talin1 at focal adhesions drive uncontrolled endothelial cell enlargement in CCM vasculature, independent of KLF2/4.

An efficient eukaryotic cell-free expression and correlative cryo-electron tomography platform

The paper develops a method to express and visualize eukaryotic proteins using cell-free systems and cryo-electron tomography, demonstrating its application to study ASC protein filaments and their interaction with ribosomes.

Mechanism of membrane curvature generation and caveola formation by flat disc-like complexes of caveolin

This study proposes a mechanism by which caveolin discs generate membrane curvature and caveola formation through lipid monolayer interactions and elastic stresses.

Targeted glycophagy ATG8 therapy reverses diabetic heart disease in mice and in human engineered cardiac tissues

This study identifies glycophagy dysregulation as a mechanism of diabetic heart disease and shows that Gabarapl1 gene therapy improves cardiac function in diabetic mice and human cardiac organoids.

A structural transition ensures robust formation of skeletal muscle

This study investigates how the zebrafish myotome forms a robust 3D structure through a structural transition involving cell rearrangement and mechanical plasticity.

A Standardized Protocol to Investigate Trans-Endothelial Trafficking in Zebrafish: Nano-bio Interactions of PEG-based Nanoparticles in Live Vasculature

This paper develops a standardized protocol to assess nanoparticle trans-endothelial trafficking in zebrafish, identifying transport mechanisms for PEG-based nanoparticles.

Maturation of human cardiac organoids are required for disease modelling and drug discovery

This study shows that maturing human cardiac organoids enhances disease modeling and drug discovery by mimicking in vivo development and enabling therapeutic testing for DSP cardiomyopathy.

Unsaturated lipids as key control points for caveola formation and disassembly

This study identifies specific unsaturated lipids as critical for caveola formation and their disassembly under oxidative stress.

New glucose-abstaining Chlorella algae doubles mammalian cell culture longevity, boosts performance and drops serum needs enabling scaled applications.

Cavin1 binding nanobodies reveal structural flexibility and regulated interactions of the N-terminal coiled-coil domain

The paper develops nanobodies that bind Cavin1's HR1 domain, revealing structural flexibility and regulated interactions important for caveolae assembly.

Lipid packing contributes to the confinement of caveolae to the plasma membrane

This study shows that lipid packing, particularly cholesterol, influences caveolae stability and dynamics in the plasma membrane.

Synaptotagmin 1 mediates toxicity of botulinum neurotoxin type A

This paper shows that botulinum neurotoxin type A (BoNT/A) toxicity relies on synaptotagmin 1 (Syt1), which forms nanoclusters with PSG and SV2 on neuronal membranes, enabling endocytic targeting and neuronal communication disruption.

Protective role of the Atg8 1 homologue Gabarapl1 in regulating cardiomyocyte glycophagy in diabetic heart disease

This study identifies Gabarapl1 as a regulator of glycophagy in diabetic cardiomyopathy, showing its role in preventing glycogen accumulation and diastolic dysfunction.