This study shows that disrupting peroxisomal-mitochondrial interactions in skeletal muscle accelerates muscle dysfunction and age-related degeneration.

Nature Communications · Nov 10, 2025Peer-reviewedCell Biology

Integrated Multi-Omics Mapping of Mitochondrial Dysfunction and Substrate Preference in Barth Syndrome Cardiac Tissue

Bauke V. Schomakers, Adriana S Passadouro, Maria M. Trętowicz, Pelle J Simpson, Yorrick R. J. Jaspers, Michel van Weeghel, Iman Man Hu, Cathelijne M. E. Lamboo, Denise Cloutier, Barry J. Byrne, Jan Bert van Klinken, Paul M.L. Janssen, Sander R. Piersma, Connie R. Jiménez, Frédéric Maxime Vaz, , Signe Mosegaard

This study analyzes heart tissue from BTHS patients using integrated omics to identify metabolic and mitochondrial changes associated with the disease.

EMBO Molecular Medicine · Oct 13, 2025Peer-reviewedMolecular Biology

Tracer-based lipidomics identifies novel disease-specific biomarkers in mitochondrial β-oxidation disorders

Marit Schwantje, Signe Mosegaard, Suzan J. G. Knottnerus, Jan Bert van Klinken, Ronald J. A. Wanders, Henk van LENTHE, Jill Hermans, Lodewijk IJlst, Simone W. Denis, Yorrick R. J. Jaspers, Sabine A. Fuchs, Riekelt H. Houtkooper, Sacha Ferdinandusse, Frédéric Maxime Vaz

The paper uses tracer-based lipidomics to identify two new disease-specific biomarkers for mitochondrial β-oxidation disorders, revealing insights into lipid metabolism and potential diagnostic applications.

bioRxiv · Aug 31, 2023 · PreprintMolecular Biology