Author

Simone W. Denis

Amsterdam University Medical Centers

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Molecular Biology· 2

Signature Assays, Organisms & Methods

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Assay:bulk RNA-seq· 1 Organism:C. elegans· 1 Research Focus:differential expression· 1 Research Focus:drug response / drug discovery· 1 Approach:experimental assay· 1 Organism:human· 1 Assay:metabolomics· 1 Approach:statistical model· 1

Frequent Co-Authors

Riekelt H. HoutkooperiD· 2 shared Aldo JongejaniD· 1 shared Bauke V. SchomakersiD· 1 shared Frédéric Maxime VaziD· 1 shared Georges E. JanssensiD· 1 shared Henk van LENTHEiD· 1 shared Jan Bert van KlinkeniD· 1 shared Jill Hermans· 1 shared

Activity by Year

2021-2023 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 27 mutual co-author links

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2 shared papersMolecular Biology

Riekelt H. HoutkooperORCID

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2 papers

Recent·Most cited

Tracer-based lipidomics identifies novel disease-specific biomarkers in mitochondrial β-oxidation disorders

Marit Schwantje, Signe Mosegaard, Suzan J. G. Knottnerus, Jan Bert van Klinken, Ronald J. A. Wanders, Henk van LENTHE, Jill Hermans, Lodewijk IJlst, Simone W. Denis, Yorrick R. J. Jaspers, Sabine A. Fuchs, Riekelt H. Houtkooper, Sacha Ferdinandusse, Frédéric Maxime Vaz

The paper uses tracer-based lipidomics to identify two new disease-specific biomarkers for mitochondrial β-oxidation disorders, revealing insights into lipid metabolism and potential diagnostic applications.

bioRxiv · Aug 31, 2023 · PreprintMolecular Biology

Inhibition of the neuromuscular acetylcholine receptor with atracurium activates FOXO/DAF-16-induced longevity

Rebecca L. McIntyre, Simone W. Denis, Rashmi Kamble, Marte Molenaars, Michael Angelo Petr, Bauke V. Schomakers, Mizanur Rahman, Siddhartha Datta Gupta, Márton L. Tóth, Siva A. Vanapalli, Aldo Jongejan, Morten Scheibye‐Knudsen, Riekelt H. Houtkooper, Georges E. Janssens

The paper identifies atracurium as an FDA-approved compound that extends lifespan and healthspan in C. elegans by activating the FOXO/DAF-16 longevity pathway through neuromuscular acetylcholine receptor inhibition.

Aging Cell · Jul 6, 2021Peer-reviewedMolecular Biology