Author

Xiaojun Lance Lian

Pennsylvania State UniversityORCID 0000-0002-9161-1004Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Research Focus:cell type annotation· 4 Approach:experimental assay· 4 Organism:human· 3 Research Focus:cell-cell communication· 2 Research Focus:clustering· 2 Assay:scRNA-seq· 2 Research Focus:cell signaling & trafficking· 1 Approach:deep learning· 1

Frequent Co-Authors

Alessandro R. HowellsiD· 2 shared Shue WangiD· 2 shared Wansheng LiuiD· 2 shared Xinran WuiD· 2 shared Ying PaniD· 2 shared Yong WangiD· 2 shared Aijun WangiD· 1 shared Andrew C. KowalczewskiiD· 1 shared

Activity by Year

2025-2026 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 17 mutual co-author links

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2 shared papersSynthetic Biology

Alessandro R. HowellsORCID

Mutual co-authors in cluster

Author profile →

5 papers

Recent·Most cited

Collagen Nanofiber Reinforced Alginate Hydrogel Tube Microbioreactors for Cell Culture

Xinran Wu, Yakun Yang, Ying Pan, Yong Wang, Xiaojun Lance Lian, Cheng Dong, Shue Wang, Aijun Wang, Wuqiang Zhu, Wansheng Liu, Yuguo Lei

This paper introduces collagen-alginate hybrid hydrogel microtubes (ColAlgTubes) that enhance cell culture efficiency by improving adhesion, mechanical stability, and scalability.

Frontiers in Bioengineering and Biotechnology · Jun 19, 2026Peer-reviewedBioengineering

Size-Modulated Mesoderm-Endoderm Divergence and Myocardial Cavitation in Micropatterned Cardioids

Plansky Hoang, David W. McKellar, Andrew C. Kowalczewski, Mai Nhu Y, Meng Chai, Xiaojun Lance Lian, Yi Zheng, Jeffrey D. Amack, Nathan R. Tucker, Iwijn De Vlaminck, Huaxiao Yang, Benjamin D. Cosgrove, Zhen Ma

This study uses micropatterned cardioids to investigate mesoderm-endoderm interactions in heart development, finding that pattern size affects cavity formation and signaling.

Advanced Science · Mar 16, 2026Peer-reviewedBioengineering

Collagen Hydrogel Tube Microbioreactors for Cell and Tissue Manufacturing

Yakun Yang, Xinran Wu, Ying Pan, Yong Wang, Xiaojun Lance Lian, Cheng Dong, Wansheng Liu, Shue Wang, Yuguo Lei

This paper introduces a collagen hydrogel tube microbioreactor system to improve cell culture scalability, robustness, and adhesion compared to alginate hydrogel tubes.

Biofabrication · Dec 2, 2025Peer-reviewedBioengineering

Gas Vesicle-Expressing Human Pluripotent Stem Cells Enable Multimodal Ultrasound and Optical Coherence Tomographic Imaging

Alessandro R. Howells, John Kim, Sumin Park, Xueding Wang, Chengzhi Shi, Xiaojun Lance Lian

This paper engineers human pluripotent stem cells to express gas vesicles, enabling noninvasive multimodal imaging via ultrasound and optical coherence tomography.

bioRxiv · Apr 10, 2025 · PreprintSynthetic Biology

Hypoimmunogenic hPSC-derived cardiac organoids for immune evasion and heart repair

Sophia E. Silver, Alessandro R. Howells, Dimitrios C. Arhontoulis, Lauren N. Randolph, Nathaniel A. Hyams, Ryan W. Barrs, Mei Li, Charles M. Kerr, Rob A. Robino, Jordan E. Morningstar, Jacelyn D. Bain, Martha E. Floy, Russell A. Norris, Xiaoping Bao, Jean Marie Ruddy, , Ying Mei

This study develops hypoimmunogenic hPSC-derived cardiac organoids that evade immune rejection and repair damaged hearts in animal models.

bioRxiv · Apr 9, 2025 · PreprintBioengineering