Masafumi Shimojo

This study identifies TRPC6 as a critical mechanosensitive channel required for ultrasound-induced neuromodulation in mammalian neurons.

The paper describes the development of triple MAPT mutation knock-in mice that exhibit early tau pathology and behavioral abnormalities, useful for studying frontotemporal dementia and related tauopathies.

The paper shows that MRS-measured Glutamate and GABA levels in awake mice correlate with excitatory and inhibitory neural activities during stimulation and in a Dravet syndrome model.

This study tracks tau fibrillogenesis and microglial phagocytosis of neurons in a living tauopathy model, showing that microglia engulf tangle-bearing neurons and that TSPO ligands can reduce this process.

This paper introduces deschloroclozapine (DCZ), a potent and selective DREADD agonist that rapidly modulates neuronal activity and behavior in mice and monkeys.

This paper develops a PET-based method using ecDHFR and TMP analogs to image neuronal networks in mammalian brains, enabling visualization of neuronal activity and protein dynamics.