He Zhang

OneGenome-Rice (OGR): A genomic foundation model for rice

OneGenome-Rice (OGR) is a genomic foundation model for rice pre-trained on 422 genomes, outperforming existing models in 11 tasks and enabling downstream applications like trait analysis and gene expression prediction.

Cell Type Architecture and Positional Gene Gradients in an Adult Animal at Subcellular Resolution

This study reconstructs 3D spatial transcriptomic models of planarians to map cell type distribution and positional gene regulation, identifying candidate genes involved in regeneration.

Caveolin-1 controls lineage fidelity of adult neural stem cells via lysosomal degradation of PDGFRα

This study shows that caveolin-1 maintains adult neural stem cell quiescence and lineage fidelity by promoting lysosomal degradation of PDGFRα.

Fluctuation of lysosomal protein degradation in neural stem cells of postnatal mouse brain

This study measures lysosomal protein degradation in neural stem cells of postnatal mouse brain and finds age and disease-related fluctuations in lysosomal activity.

The immune vulnerability landscape of the 2019 Novel Coronavirus, SARS-CoV-2

The paper predicts T cell and B cell immunogenic epitopes of SARS-CoV-2 using genomic data and compares them with SARS-CoV and MERS-CoV to identify immune vulnerability patterns.

A chromosome-level assembly of the Atlantic herring - detection of a supergene and other signals of selection

The paper presents a chromosome-level genome assembly of Atlantic herring, enabling the detection of a supergene and improved analysis of selection signals.