Author

David Laurence Becker

Nanyang Technological UniversityORCID 0000-0002-9300-0899Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Microbiology· 1 Neuroscience· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Research Focus:differential expression· 1 Research Focus:host-pathogen & immune response· 1 Organism:human· 1 Organism:mouse· 1 Assay:proteomics· 1

Frequent Co-Authors

Agueda A. RostagnoiD· 1 shared André StrydomiD· 1 shared Anne Rovelet‐LecruxiD· 1 shared Annette Karmiloff‐Smith· 1 shared Aoife MurrayiD· 1 shared Carla Marie StartiniD· 1 shared Cheryl Jia Yi NeoiD· 1 shared Claudia J. StocksiD· 1 shared

Activity by Year

2020-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 29 mutual co-author links

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1 shared paperNeuroscience

Agueda A. RostagnoORCID

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2 papers

Recent·Most cited

Enterococcus faecium colonization and persistence in a model of diabetic wound infection

Navin Jeyabalan, Frederick Reinhart Tanoto, Haris Antypas, Cheryl Jia Yi Neo, Rachel Jing Wen Tan, Kévin Pethe, David Laurence Becker, Claudia J. Stocks, Kimberly A. Kline

This study uses a diabetic mouse model to show that Enterococcus faecium persists in wounds due to impaired clearance and altered immune responses compared to non-diabetic mice.

Infection and Immunity · Apr 30, 2026Peer-reviewedMicrobiology

Patient-specific Alzheimer-like pathology in trisomy 21 cerebral organoids reveals BACE2 as a gene-dose-sensitive AD-suppressor in human brain

Ivan Alić, Pollyanna Agnes Goh, Aoife Murray, Erik Portelius, Eleni Gkanatsiou, Gillian Gough, Kin Ying Mok, David Koschut, Reinhard Brunmeir, Yee Jie Yeap, Niamh Louise O’Brien, Jürgen Groet, Xiaowei Shao, Steven Havlicek, Norris Ray Dunn, , Henrik Zetterberg

The paper shows that trisomy 21 cerebral organoids exhibit AD-like pathology, which can be suppressed by BACE2 trisomy and inhibited by BACE1 inhibitors, suggesting BACE2 as an AD-suppressor gene.

Molecular Psychiatry · Jul 9, 2020Peer-reviewedNeuroscience