Samet Aytekin

Letting go to hold on: loss of CCM2 disrupts endothelial force balance in cerebral cavernous malformations

This study investigates how loss of CCM2 disrupts endothelial force balance in cerebral cavernous malformations by analyzing molecular forces and adhesion organization.

Synthesis and mechanical characterization of polyacrylamide (PAAm) hydrogels with different stiffnesses for large-batch cell culture applications

This paper provides a step-by-step protocol for synthesizing and characterizing PAAm hydrogels of varying stiffness for cell culture and mechanobiology studies.

Quantitative Analysis of Cytoplasmic Viscosity in Colorectal Cancer Cells by Differential Dynamic Microscopy of Genetically Encoded Nanoparticles

This paper introduces GEM-DDM, a method using genetically encoded nanoparticles and differential dynamic microscopy to measure cytoplasmic viscosity in living cells, showing increased viscosity in aggressive colorectal cancer cells.

From Sensor Design to Force Maps: A Systematic Evaluation of FRET-based Vinculin Tension Sensors

The paper evaluates FRET-based vinculin tension sensors to determine optimal design parameters for measuring molecular forces in cells.

Deciphering stiffness-driven changes in colorectal cancer by proteomics

This study shows that matrix stiffness in colorectal cancer alters secreted protein expression, enhancing migration, angiogenesis, and matrix remodeling, contributing to a more aggressive cancer phenotype.

Linking Molecular Tension and Cellular Tractions: A Multiscale Approach to Focal Adhesion Mechanics

This study combines Traction Force Microscopy and Vinculin Tension Sensors to analyze how molecular tension and cellular tractions interact across different scales in focal adhesions.