Maria Tokuyama

Identification of a set of endogenous retroviruses linked to IL-1-mediated immunopathology in severe COVID-19.

This study identifies ERVs linked to IL-1-mediated immunopathology in severe COVID-19 using bulk and single-cell RNA-sequencing data from multiple cohorts.

Modeling herpes simplex virus type 2 and Zika virus replication in vaginal organoids and spheroids

This study shows that vaginal organoids support HSV-2 and ZIKV replication and respond to antiviral drugs, with differences in drug efficacy between mouse organoids and human spheroids.

Loss of α2,3-linked sialoside in the receptor-binding site of a H5N1 influenza hemagglutinin identified in a human patient

The paper identifies a H5N1 influenza strain with reduced sialic acid binding due to loss of α2,3-linked sialoside in its HA receptor-binding site, correlating with lower virulence despite severe disease.

Viral proteins and virus-like particles of the LTR5_Hs endogenous retrovirus in human primordial germ cell-like cells

The paper identifies LTR5_Hs viral proteins and virus-like particles in hPGCLCs, showing their activation during early germ cell development and suppression upon gonadal anlagen settlement.