Sergiy Sylantyev

A brainstem to hypothalamic arcuate nucleus GABAergic circuit drives feeding

The paper identifies GABAergic neurons in the nucleus of the solitary tract (NTS) as a new modulator of feeding behavior and body weight by suppressing orexigenic AgRP/NPY neurons through projections to the hypothalamic arcuate nucleus.

Volume-transmitted GABA waves pace epileptiform rhythms in the hippocampal network

The paper shows that volume-transmitted GABA waves drive epileptiform rhythms in hippocampal networks by elevating tonic GABAA receptor conductance across multiple cells.

Protein aggregation and calcium dysregulation are the earliest hallmarks of synucleinopathy in human midbrain dopaminergic neurons

This study uses hiPSCs with SNCA mutations to identify early molecular events in synucleinopathy, showing protein aggregation precedes functional impairments in midbrain dopaminergic neurons.

Highly enriched hiPSC-derived midbrain dopaminergic neurons robustly models Parkinson's disease.

This paper develops a method to generate highly enriched midbrain dopaminergic neurons from hiPSCs, which model Parkinson's disease features like synucleinopathy and mitochondrial dysfunction.

Extracellular GABA waves regulate coincidence detection in excitatory circuits

The paper shows that extracellular GABA concentration modulates coincidence detection in excitatory circuits by affecting membrane shunting via GAT-1.