Author

Shabaana A. Khader

Istituto Nazionale per le Malattie Infettive Lazzaro SpallanzaniORCID 0000-0002-9545-4982Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Immunology· 4 Bioinformatics· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Research Focus:host-pathogen & immune response· 3 Research Focus:cell type annotation· 2 Organism:human· 2 Organism:mouse· 2 Organism:non-human primate· 2 Assay:proteomics· 2 Approach:statistical model· 2

Frequent Co-Authors

Deepak KaushaliD· 3 shared Annu DeviiD· 2 shared Smriti MehraiD· 2 shared Abhimanyu AbhimanyuiD· 1 shared Ahmed Saif· 1 shared Alea C. DelmastroiD· 1 shared Alessandra D’AbramoiD· 1 shared Alessandro CaponeiD· 1 shared

Activity by Year

2020-2026 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 11 mutual co-author links

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3 shared papersImmunology

Deepak KaushalORCID

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Author profile →

5 papers

Recent·Most cited

Therapeutic remodeling of the tuberculosis granuloma with 1-methyl-D-tryptophan enhances CD8+ T cell-macrophage interactions

Erin McCaffrey, Alea C. Delmastro, Bindu Singh, Annu Devi, Caden W. Munson, Priyanka, Nadia Golden, Shabaana A. Khader, Michael Angelo, Deepak Kaushal, Smriti Mehra

This study shows that D-1MT treatment enhances CD8+ T cell infiltration and interactions with macrophages in TB granulomas, improving immune control of Mtb.

Proceedings of the National Academy of Sciences · Aug 11, 2026Peer-reviewedImmunology

Bronchus associated lymphoid tissue induced by an attenuated Mycobacterium tuberculosis vaccine prevents tuberculosis from heterologous TB challenge

Dhiraj K. Singh, Garima Arora, Venkata Siva Reddy Devireddy, Annu Devi, Mushtaq Ahmed, Vinay Shivanna, Korri S. Weldon, Shannan Hall-Ursone, Zhao Lai, Smriti Mehra, Xavier A. Alvarez, Shabaana A. Khader, Deepak Kaushal

This study shows that an attenuated Mycobacterium tuberculosis vaccine induces bronchus-associated lymphoid tissue (iBALT) and protects against heterologous TB challenge in macaques.

bioRxiv · May 26, 2026 · PreprintImmunology

Mast cells promote pathology and susceptibility in tuberculosis

Ananya Gupta, Vibha Taneja, Javier Rangel‐Moreno, Nilofer Naqvi, Abhimanyu Abhimanyu, Yun Tao, Mushtaq Ahmed, Kuldeep Singh Chauhan, Daniela Trejo-Ponce de León, Gustavo Ramírez-Martínez, Luis Armando Jiménez-Álvarez, César Luna-Rivero, Joaquı́n Zúñiga, Deepak Kaushal, Shabaana A. Khader

This study shows mast cells drive tuberculosis pathology by promoting inflammation and Mtb dissemination, with distinct transcriptional programs in active versus latent infection.

eLife · Jan 28, 2026Peer-reviewedImmunology

β-Glucan Reprograms Neutrophils to Induce Disease Tolerance Against Influenza A Virus

Nargis Khan, Kim A. Tran, Raphaël Chèvre, Veronica Locher, Mathis Richter, Sarah Sun, Mina Sadeghi, Erwan Pernet, Andrea Herrero-Cervera, Alexandre Grant, Ahmed Saif, Jeffrey Downey, Eva Kaufmann, Shabaana A. Khader, Philippe Joubert, , Maziar Divangahi

This study shows β-glucan reprograms neutrophils to induce disease tolerance against Influenza A virus by promoting a unique subset of neutrophils that limit tissue damage and enhance survival.

Nature Immunology · Jan 8, 2025Peer-reviewedImmunology

COVID-19: Viral-host interactome analyzed by network based-approach model to study pathogenesis of SARS-CoV-2 infection.

Francesco Messina, Emanuela Giombini, Chiara Agrati, Francesco Vairo, Tommaso Ascoli Bartoli, Samir Al Moghazi, Mauro Piacentini, Franco Locatelli, Gary Kobinger, Markus J. Maeurer, Alimuddin I. Zumla, Maria Rosaria Capobianchi, F. Lauria, Giuseppe Ippolito, COVID 19 INMI Network Medicine for IDs Study Group, , Nicola Segata

The paper analyzes the viral-host interactome of SARS-CoV, MERS-CoV, and HCoV-229E using a network-based approach to predict SARS-CoV-2 pathogenesis.

Journal of Translational Medicine · Jun 10, 2020Peer-reviewedBioinformatics