Estefania P. Azevedo

Efficacy of glucocorticoid modulator PT150 as a weight loss strategy

This study evaluates PT150, a GR antagonist, as a weight loss strategy in combination with semaglutide in diet-induced obese mice, showing improved weight reduction and setpoint maintenance.

Molecular and cellular adaptations in hippocampal parvalbumin neurons mediate behavioral responses to chronic social stress

A molecularly defined insular cortex --> central amygdala circuit mediates conditioned overconsumption of food.

The paper identifies a circuit between the insular cortex and central amygdala that promotes overconsumption by suppressing satiety signals through nitric oxide synthase-1 neurons.

A Developmental Role for Microglial Presenilin 1 in Memory

This study shows that deleting Presenilin 1 in microglia during development enhances memory and neuronal activity in mice, with effects dependent on GluN2B and mitigating Alzheimer's symptoms.

A limbic circuit selectively linking active escape to food suppression

This study identifies stress-responsive neurons in the lateral septum that reduce food intake and body weight through hypothalamic pathways.

Encoding of an engram for food location by satiety-promoting Drd2 hippocampal neurons

This study identifies hippocampal D2R neurons that regulate feeding behavior and encode food location memory through a LEC->Hippocampus->Septal circuit.

Control of non-homeostatic feeding in sated mice using associative learning of contextual food cues

This paper develops a context-induced feeding task to study non-homeostatic feeding in mice and identifies brain regions involved in appetitive conditioning.