HTRF-based identification of small molecules targeting SARS-CoV-2 E protein interaction with ZO-1 PDZ2
Flavio Alvarez, Florence Larrous, Ariel Méchaly, Benjamin Bardiaux, Quentin GOOR, Ahmed Haouz, Blandine Séon‐Méniel, Rodolphe Alves de Sousa, Stéphane Bourg, Didier Desmaële, Bruno Figadère, Nicolas Wolff, Hélène Munier‐Lehmann, Célia Caillet‐Saguy
This paper identifies small molecules that inhibit the SARS-CoV-2 E protein interaction with ZO-1 PDZ2 using X-ray crystallography, HTRF screening, and docking simulations, with one compound showing antiviral activity.
Scientific Reports · Dec 28, 2025Peer-reviewedBiochemistry