Keira Y. Larson

IL15/IL15Rα complex induces an anti-tumor immune response following radiation therapy only in the absence of Tregs and fails to induce expansion of progenitor TCF1+ CD8 T cells

This study shows that IL15/IL15Rα complex with radiation therapy requires Treg depletion to induce anti-tumor immunity and that PD1-IL2v enhances CD8 T cell activation and function.

Discerning Specific Thrombolytic Activities and Blood Clot Degradomes of Diverse Snake Venoms with Untargeted Peptidomics

This study uses untargeted peptidomics and thrombolysis assays to analyze the clot-degrading effects of six snake venoms, revealing specific targets and mechanisms of thrombolysis.

PP1 PNUTS binds the restrictor and dephosphorylates RNA pol II CTD Ser5 to stimulate transcription termination

The paper identifies PP1 phosphatase activity in the PPWZ complex as essential for antisense transcription termination by dephosphorylating RNA pol II CTD Ser5.