Aditya Natu

Delayed Tagging of ED-A Fibronectin-Mimetic Peptide in an RGD-Decorated Synthetic Matrix Induces Fibroblast-to-Myofibroblast Transition

This study shows that delayed introduction of EDG in an RGD-decorated hydrogel promotes fibroblast-to-myofibroblast transition by increasing myofibroblast markers and ECM proteins.

Bioorthogonal Tuning of Hydrogel Stiffness Promotes Zonal Redifferentiation of Passaged Chondrocytes

This study shows that tunable hydrogels can enhance zone-specific chondrocyte phenotypes and promote zonally organized cartilage formation.

Aβ Amyloid Scaffolds the Accumulation of Matrisome and Additional Proteins in Alzheimer's Disease

The paper identifies a conserved Aβ amyloid 'responsome' in human and mouse AD brains, showing how amyloid scaffolds proteins involved in disease pathology.

Proximity labeling proteomics reveals Kv1.3 potassium channel immune interactors in microglia.

The paper identifies Kv1.3 potassium channel interactors in microglia using proximity labeling proteomics, revealing domain-specific interactions with immune signaling proteins during inflammation.

Identification of state-specific proteomic and transcriptomic signatures of microglia-derived extracellular vesicles

The paper identifies state-specific proteomic and transcriptomic signatures of microglia-derived extracellular vesicles using proteomic and transcriptomic analyses.

Native-state proteomics of Parvalbumin interneurons identifies novel molecular signatures and metabolic vulnerabilities to early Alzheimer's disease pathology

Cellular proteomic profiling using proximity labelling by TurboID-NES in microglial and neuronal cell lines.

The paper uses TurboID-NES to profile proteomes of microglial and neuronal cell lines, showing it captures a significant portion of the proteome and responds to LPS treatment.