Pablo Pelegrı́n

The inflammasome adaptor protein ASC present differential intracellular and extracellular functions to trigger immunometabolic dysregulation anddysbiosis during obesity

This study shows ASC has both intracellular and extracellular roles in obesity-induced inflammation and dysbiosis, suggesting it as a therapeutic target.

Cardiolipin Inhibits the Noncanonical Inflammasome by Preventing LPS Binding to Caspase 4/11 to Mitigate Endotoxemia in Vivo

This study identifies cardiolipin as a selective inhibitor of caspase 4/11 that prevents LPS-induced inflammation without affecting caspase-1, offering a potential therapeutic for Gram-negative sepsis.

Gasdermin D mediates a fast transient release of ATP after NLRP3 inflammasome activation before ninjurin 1-induced lytic cell death

This study shows GSDMD-mediated ATP release as an early transient danger signal during NLRP3 inflammasome activation, preceding cell death and IL-1β release.

ND-13, a DJ-1 derived peptide, as a novel pharmacological approach in the prevention of NLRP3 inflammasome activity in Diabetic Nephropathy

This study investigates ND-13, a DJ-1-derived peptide, showing its ability to reduce NLRP3 inflammasome activity and renal damage in diabetic nephropathy models.