Muhammad Ayub

Rare coding variation implicates thirteen genes in bipolar disorder across 232,536 individuals from global populations

Analysis of Rare Coding Variation Identifies New Genetic Contributors to Schizophrenia

Ultra-rare damaging coding variants in 87,959 schizophrenia cases and 150,587 controls implicate 40 genes (16 exome-wide, 24 at 5% FDR), half overlapping autism, developmental delay or bipolar genes.

Decoding the neural basis of sensory phenotypes in Autism

This study identifies unique functional connectivity patterns in autism associated with five sensory processing phenotypes using machine learning.

dGAMLSS: An exact, distributed algorithm to fit Generalized Additive Models for Location, Scale, and Shape for privacy-preserving population reference charts

The paper introduces dGAMLSS, a distributed algorithm for fitting GAMLSS models to construct population reference charts without sharing patient data.

Using deep learning to predict internalizing problems from brain structure in youth

This study uses deep learning to predict internalizing problems from brain structure in youth, finding good performance in neurodevelopmental conditions but sub-optimal in the general population.

Functional organization of multisensory integration network in children and youth with neurodevelopmental disorders predicts clinical sensory issues

The paper examines multisensory integration network (MSN) functional connectivity in neurodevelopmental disorders and finds that sensory characteristics, not diagnoses, drive the observed neural patterns.

Profiling brain morphology for autism spectrum disorder with two cross-culture large-scale consortia

This study identifies two ASD subgroups with distinct brain morphology using cross-cultural datasets, highlighting key brain regions associated with subgroup characteristics and autistic traits.

A cross-disorder analysis of CNVs finds novel loci and dose-dependent relationships of genes to psychiatric traits

The paper identifies novel CNV loci and dose-dependent gene effects across six psychiatric disorders using genome-wide analysis.

Psychiatric disorders converge on common pathways but diverge in cellular context, spatial distribution, and directionality of genetic effects

The paper identifies shared and divergent genetic mechanisms across psychiatric disorders using gene-set burden analysis of copy number variants.

Assigning Targetable Pathways to Transdiagnostic Subgroups Across Neurodevelopmental Disorders

The paper identifies molecular pathways associated with neurodevelopmental disorder subgroups using neuroimaging data from mice and humans.

Evaluation of imputation performance of multiple reference panels in a Pakistani population

This study evaluates imputation performance of reference panels in a Pakistani population, finding that ex1KG outperforms TOPMed despite its smaller size.

Dataset factors associated with age-related changes in brain structure and function in neurodevelopmental conditions

The paper examines age-related changes in brain structure and function across two neurodiverse datasets, finding differences linked to demographic and clinical factors.

A longitudinal resource for population neuroscience of school-age children and adolescents in China

The paper introduces a longitudinal dataset of school-age children and adolescents in China, detailing its design, sampling, and neuroimaging measurements.

Brain charts for the human lifespan

The paper introduces brain charts as a standardized resource for benchmarking brain morphology across the human lifespan using MRI data from a large and diverse cohort.

Rare schizophrenia risk variant burden is conserved in diverse human populations

The paper investigates the conservation of rare schizophrenia risk variants across diverse populations and finds consistent burden in constrained genes.

Autism spectrum disorder trios from consanguineous populations are enriched for rare biallelic variants, identifying 32 new candidate genes

Low-frequency variation in TP53 has large effects on head circumference and intracranial volume

The paper identifies 9 novel genetic loci, including low-frequency variants in TP53, associated with head circumference and intracranial volume in up to 46,000 individuals.

Mapping Autosomal Recessive Intellectual Disability: Combined Microarray and Exome Sequencing Identifies 26 Novel Candidate Genes in 192 Consanguineous Families

Rare loss-of-function variants in KMT2F are associated with schizophrenia and developmental disorders

The paper identifies rare loss-of-function variants in KMT2F associated with schizophrenia and developmental disorders, showing their role in neurodevelopmental conditions.