Meng Zhang

A molecularly defined and spatially resolved cell atlas of the whole mouse brain

MERFISH profiling of >1,100 genes in ~8 million cells spanning the whole mouse brain, integrated with scRNA-seq, maps >5,000 clusters into the Allen Common Coordinate Framework.

A high-resolution transcriptomic and spatial atlas of cell types in the whole mouse brain

This paper creates a high-resolution transcriptomic and spatial cell type atlas of the whole adult mouse brain, revealing spatial organization and transcription factor codes for cell types.

Conservation and divergence in cortical cellular organization between human and mouse revealed by single-cell transcriptome imaging

This study compares cellular organization and interactions in human and mouse cortex using single-cell transcriptome imaging, finding conserved laminar organization but divergent cell-cell interactions in humans.

Deep learning and alignment of spatially-resolved whole transcriptomes of single cells in the mouse brain with Tangram

The paper introduces Tangram, a method that aligns single-nucleus RNA-seq data with spatial data to create an anatomically integrated spatial map of the mouse brain.

A multimodal cell census and atlas of the mammalian primary motor cortex

The paper generates a multimodal cell census and atlas of the mammalian primary motor cortex, revealing a unified molecular genetic landscape and cross-species taxonomy of cell types.

Molecular, spatial and projection diversity of neurons in primary motor cortex revealed by in situ single-cell transcriptomics

MERFISH imaging of ~300,000 mouse primary motor cortex cells yields 95 clusters, layered inhibitory as well as excitatory, with intratelencephalic neurons forming a depth-linked expression gradient.